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tepA [2017-8-11 16:0:3]
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tepA [2017-8-11 16:0:3]

orphan ClpP-like germination protease, contributes to SASP degradation
locus
BSU16790
pI
5.57
mw
24.10 kDa
protein length
223 aa Sequence Blast
gene length
669 bp Sequence Blast
function
degradation of SASPs
product
germination protease
essential
no
synonyms
ymfB, ylxI
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.3|Proteolysis during sporulation/ germination]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.4|Germination] → [category|SW 4.2.4.2|Additional germination proteins]

    • Gene

    Coordinates
    1,751,201 → 1,751,938

    The protein

    Catalyzed reaction/ biological activity

  • degradation of SASPs in germinating spores [Pubmed|23927687]

    • Protein family

  • TepA subfamily (according to Swiss-Prot)

    • Effectors of protein activity

  • activity requires [protein|A7C95C19ABD47456351C05A88B14F932BDEF1059|YlzJ] [Pubmed|23927687]

    • [SW|Localization]

  • inner spore membrane [Pubmed|26731423]

    • Expression and Regulation

    Operons

    genes
    [gene|A16C6515D185E3A268D57D77F28EF7EF9AF9FE05|tepA]-[gene|A7C95C19ABD47456351C05A88B14F932BDEF1059|ylzJ]
    description
    [Pubmed|22383849]

    sigma factors

  • [protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|SigG]: sigma factor, [Pubmed|23123912], in [regulon|5F24258282F3166B7696B9E9ABC1706E4D06C944|SigG regulon]

    • regulatory mechanism

  • [protein|01EF886D3D004EA9B22AC5E75D50FF07D8631E68|SpoVT]: repression, [Pubmed|23123912], in [regulon|01EF886D3D004EA9B22AC5E75D50FF07D8631E68|SpoVT regulon]

    • regulation

  • expressed late during [SW|sporulation] in the forespore ([protein|search|SigG], [SW|SpoVT]) [Pubmed|23123912]
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    Biological materials

    Mutant

  • MGNA-B377 (ymfB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1376 NBRP B. subtilis, Japan]
  • GP1120 (spc), available in the [SW|Stülke] lab

    • References

  • 23123912,22383849,10455123,23927687,26731423